Iran's Supreme Leader Ayatollah Ali Khamenei delivered a sharply worded televised address on Thursday, warning the United States that "military adventurism in the Persian Gulf will be met with a response that will make the aggressor regret its actions for a generation."

Speaking from Tehran before a gathering of IRGC commanders, Khamenei said Iran would not be intimidated by the U.S. naval buildup. "They bring their ships into our waters and call it freedom of navigation. They shoot down our aircraft and call it self-defense. The world is not blind to this theater," he said.

The address marked Khamenei's first public comments since the drone shoot-down earlier Thursday. He dismissed U.S. claims about the incident, calling them "fabrications designed to justify aggression," but stopped short of announcing specific retaliatory measures.

Khamenei also rejected growing international calls for negotiations, stating flatly that "a nation under threat does not sit at the negotiating table with the hand that holds the sword." The remarks appeared to close the door on European and regional mediation efforts that had gained momentum earlier in the week.

Iranian Foreign Minister Abbas Araghchi, speaking separately at a press conference, struck a more measured tone. He said Iran remained committed to diplomatic channels "in principle" but that the U.S. must first de-escalate by pulling its carrier strike group out of the Gulf.

"We will not reward threats with concessions," Araghchi said. "De-escalation must be mutual and verifiable."